:root{--ink:#342044;--forest:#633478;--subtle:#74617e;--line:#e8d7e8;--page:#fff7fb;--white:#fff;--accent:#ffe1ef;--danger:#a13a2d;--soft-danger:#fff2ec;--radius:20px}*{box-sizing:border-box}html{scroll-behavior:smooth;scroll-padding-top:100px}body{margin:0;background:var(--page);font-family:Inter,-apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif;color:var(--ink);font-size:15px;line-height:1.5}a{color:inherit}button,input,select{font:inherit}button,a,input,select{touch-action:manipulation}button{cursor:pointer}button:disabled{cursor:not-allowed;opacity:.55}[hidden]{display:none!important}:focus-visible{outline:3px solid #a84485;outline-offset:4px}.wrap{max-width:1160px;margin:auto;padding:0 36px}.skip{position:absolute;left:20px;top:-80px;background:#fff;padding:12px;z-index:10}.skip:focus{top:12px}.header{height:98px;background:rgba(255,247,251,.96);border-bottom:1px solid var(--line)}.nav{height:100%;display:flex;align-items:center;gap:50px}.brand{font-weight:750;font-size:22px;letter-spacing:-.8px;display:flex;align-items:center;text-decoration:none;white-space:nowrap}.brand-light{font-weight:450}.brand-icon{display:grid;place-items:center;background:var(--forest);color:var(--accent);height:35px;width:35px;border-radius:10px;margin-right:10px;font-size:22px}.nav nav{display:flex;gap:26px;font-size:13px}.nav nav a{text-decoration:none;color:#6a4b78}.nav nav a:hover{color:var(--forest)}.professional{margin-left:auto;font-size:11px;border:1px solid #ead0e2;border-radius:30px;padding:8px 12px;background:#faeaf3;font-weight:600;white-space:nowrap}.hero{padding:65px 0 54px;display:flex;align-items:center;justify-content:space-between;gap:45px}.eyebrow{font-size:10px;font-weight:700;letter-spacing:1.6px;margin:0 0 17px;display:flex;align-items:center;gap:9px}.dot{height:6px;width:6px;background:#b13c7b;border-radius:50%}h1,h2,h3,p{margin-top:0}h1{font-weight:550;font-size:46px;line-height:1.13;letter-spacing:-2px;margin-bottom:21px}h2{font-weight:550;font-size:28px;letter-spacing:-1px;line-height:1.2;margin-bottom:0}h3{font-size:18px;font-weight:600;letter-spacing:-.5px;margin-bottom:4px}.hero-text{font-size:15px;line-height:1.7;color:var(--subtle);margin-bottom:0}.hero-note{border-left:1px solid #e8ccdf;padding-left:28px;min-width:205px}.note-symbol{display:block;font-size:33px;color:#a64e91;margin-bottom:11px}.hero-note strong{font-size:16px;line-height:1.5;font-weight:550}.hero-note p{color:var(--subtle);font-size:12px;line-height:1.8;margin:11px 0 0}.section-heading{display:flex;justify-content:space-between;align-items:flex-end;gap:20px;margin-bottom:23px}.section-heading .eyebrow{margin-bottom:8px}.muted{color:#796582}.text-button{border:0;background:none;color:var(--subtle);display:flex;gap:6px;align-items:center;padding:7px 0;font-size:12px}.text-button:hover{color:var(--ink)}.calculator-grid{display:grid;grid-template-columns:1.15fr 1fr;gap:24px;align-items:stretch}.form-card{background:var(--white);border:1px solid var(--line);border-radius:var(--radius);padding:31px 33px 23px;box-shadow:0 5px 16px #54265e08}.step-heading{display:flex;gap:13px;align-items:center;margin-bottom:23px}.step-number{height:31px;width:31px;flex:0 0 31px;border-radius:50%;background:#faeaf3;border:1px solid #efd2e4;display:grid;place-items:center;font-size:12px;font-weight:650}.step-heading h3{font-size:18px;margin-bottom:2px}.step-heading p{font-size:12px;color:var(--subtle);margin:0}label{font-size:12px;font-weight:650;display:block;margin-bottom:8px}select,input[type=text]{width:100%;border:1px solid #dcc6df;border-radius:9px;background:#fff;color:var(--ink);height:49px;padding:0 14px;font-size:14px}select{padding-right:30px}.dose-label{display:flex;align-items:center;justify-content:space-between;margin-top:20px}.dose-label span{font-size:10px;color:#7d6785}.dose-control{position:relative}.dose-control input{padding-right:48px;font-size:18px}.dose-control>span{position:absolute;right:15px;top:13px;color:#7b6386;font-size:13px}.help{font-size:10px;color:#7c6984;margin:7px 0 0}.step-divider{height:44px;display:flex;align-items:center;position:relative;margin:12px 0 7px}.step-divider:before{content:"";height:1px;background:var(--line);position:absolute;width:100%}.step-divider span{background:#fff;z-index:1;color:#a379aa;padding:0 9px;font-size:21px;margin-left:2px}.primary-button{width:100%;border:0;border-radius:9px;background:var(--forest);color:#fff;font-weight:550;font-size:14px;display:flex;justify-content:space-between;align-items:center;padding:15px 18px;margin-top:26px;transition:background .15s}.primary-button:hover:not(:disabled){background:#8d235e}.primary-button span{font-size:20px;line-height:1}.form-foot{font-size:10px;text-align:center;color:#7c6885;margin:12px 0 0}.result-card{border-radius:var(--radius);background:#f9e5f1;border:1px solid #eac5de;padding:28px 30px 24px;display:flex;flex-direction:column;overflow:hidden;position:relative}.result-top{display:flex;align-items:center;justify-content:space-between}.result-top .eyebrow{font-size:9px;color:#77517f;margin:0}.result-mark{display:grid;place-items:center;border:1px solid #ddb2d2;height:29px;width:29px;border-radius:50%;font-size:20px;color:#9a62a3}.empty-result{padding:69px 0 67px;text-align:center}.empty-symbol{font-size:32px;margin-bottom:20px;color:#a867a7}.empty-result h3{font-weight:500;font-size:27px;line-height:1.25;letter-spacing:-.8px;margin-bottom:15px}.empty-result p{color:#7e6087;font-size:12px;line-height:1.8;max-width:260px;margin:auto}.result-footer{margin-top:auto;border-top:1px solid #e2bad7;padding-top:19px;display:flex;gap:9px;color:#795681}.result-footer>span{font-size:14px}.result-footer p{font-size:10px;line-height:1.7;margin:0}.result-content{padding:31px 0 26px}.result-route{display:flex;flex-direction:column;gap:4px;font-size:12px;color:#76507e}.result-route strong{font-size:15px;font-weight:600;color:var(--ink)}.result-label{font-size:10px;letter-spacing:1.4px;color:#76507e;font-weight:650;margin:31px 0 9px}.dose-result{font-size:62px;line-height:1.15;font-weight:550;letter-spacing:-3px;margin:0}.dose-result .unit{font-size:22px;letter-spacing:-.5px;margin-left:7px;font-weight:450}.result-target{font-size:16px;font-weight:550;margin:7px 0 19px;overflow-wrap:anywhere}.result-description{font-size:12px;color:#76507e;margin:15px 0 0;line-height:1.7}.result-status{font-size:23px;font-weight:550;letter-spacing:-.6px;line-height:1.4;margin:22px 0}.result-status.warning{color:#983c2f}.legacy-edge{font-size:11px;line-height:1.7;border-top:1px solid #e2bad7;padding-top:14px;color:#875133;margin-top:20px}.notice{padding:12px 15px;border:1px solid #e5d0b9;border-radius:9px;background:#fff8ed;color:#805735;font-size:12px;line-height:1.6;margin:12px 0}.notice.compact{font-size:11px;padding:9px 11px;margin:10px 0 0}.notice.danger,.field-error{color:var(--danger)}.notice.danger{background:var(--soft-danger);border-color:#edcfc3}.field-error{font-size:11px;margin:7px 0 0}input[aria-invalid=true],select[aria-invalid=true]{border-color:#b9513f}.profiles-section{margin-top:54px}.small-label{font-size:10px;color:#7e6687;padding-bottom:3px}.profiles-grid{display:grid;grid-template-columns:1fr 1fr;gap:24px}.profile{background:white;border:1px solid var(--line);border-radius:var(--radius);padding:26px 28px}.profile-label{font-size:9px;color:#86698d;letter-spacing:1.3px;font-weight:700}.profile h3{font-size:20px;margin:13px 0 21px;line-height:1.35;font-weight:550}.profile.placeholder{padding-bottom:40px}.profile.placeholder h3{color:#7e6687;margin-bottom:10px}.profile.placeholder p{color:#816a8b;font-size:12px;margin:0}.profile dl{margin:0}.profile .detail-row{display:grid;grid-template-columns:40% 60%;border-top:1px solid #f3e7f1;padding:13px 0;gap:12px;font-size:11px}.profile dt{color:#7d6687}.profile dd{margin:0;color:#51355e;padding-right:12px;white-space:pre-wrap;overflow-wrap:anywhere}.profile details{margin-top:10px}.profile summary{font-size:11px;font-weight:600;cursor:pointer;padding:9px 0;color:#87518f}.profile summary:hover{color:#512266}.how-section{display:grid;grid-template-columns:1fr 1fr;gap:70px;border-top:1px solid var(--line);padding:46px 0 48px;margin-top:53px}.how-section>div>p:last-child{font-size:12px;color:var(--subtle);max-width:285px;line-height:1.8;margin-top:16px}.how-section h2,.about-section h2{font-size:31px;line-height:1.2}.how-section ol{list-style:none;margin:0;padding:0}.how-section li{display:flex;gap:21px;padding:0 0 22px}.how-section li:last-child{padding-bottom:0}.how-section li>span{font-size:11px;color:#986c9e;padding-top:2px}.how-section li h3{font-size:14px;letter-spacing:-.2px;margin-bottom:5px}.how-section li p{font-size:11px;color:var(--subtle);margin:0;line-height:1.8}.about-section{display:grid;grid-template-columns:1fr 1fr;gap:70px;border-top:1px solid var(--line);padding:43px 0}.about-section>div>p:not(.eyebrow){font-size:12px;color:var(--subtle);line-height:1.9;margin-bottom:12px}.inline-link{font-size:12px;font-weight:600;text-underline-offset:4px}.clinical-notice{display:flex;gap:14px;border:1px solid #e6dfd0;background:#f4f0e7;border-radius:13px;padding:23px 25px;margin:4px 0 50px}.clinical-notice>span{display:grid;place-items:center;border:1px solid #b4a78b;color:#9a8560;border-radius:50%;height:21px;flex:0 0 21px;font-size:12px}.clinical-notice strong{font-size:12px;font-weight:600;color:#6d644f}.clinical-notice p{font-size:11px;color:#91856e;line-height:1.8;margin:7px 0 0}.footer{border-top:1px solid var(--line);padding:28px 0 32px}.footer>.wrap{display:flex;align-items:center;gap:25px}.footer .brand{font-size:17px;letter-spacing:-.5px}.footer p{font-size:10px;color:#816c8b;margin:0}.footer nav{display:flex;gap:22px;margin-left:auto;font-size:10px;color:#796183}.footer nav a{text-decoration:none}dialog{border:1px solid var(--line);border-radius:20px;padding:33px;max-width:480px;width:calc(100% - 32px);color:var(--ink);box-shadow:0 20px 80px #4a245b22}dialog::backdrop{background:#4c245b4d;backdrop-filter:blur(4px)}dialog form{position:relative}dialog h2{margin:0 0 18px;font-size:29px}dialog p{font-size:13px;line-height:1.8;color:var(--subtle)}.dialog-close{position:absolute;right:-14px;top:-24px;background:transparent;border:0;color:var(--subtle);font-size:27px}.terms-check{display:flex;align-items:flex-start;gap:12px;font-size:12px;font-weight:450;line-height:1.8;margin-top:24px}.terms-check input{width:16px;height:16px;flex:0 0 16px;margin-top:3px;accent-color:var(--forest)}.prose{padding:40px;max-width:870px;background:#fff;border:1px solid var(--line);border-radius:20px;margin:30px auto 60px;line-height:1.9;font-size:14px}.prose h1{font-size:34px}.prose h2{font-size:24px;margin:30px 0 15px}.prose p{white-space:pre-line}.prose table{border-collapse:collapse;width:100%;font-size:12px}.prose th,.prose td{border-bottom:1px solid var(--line);padding:12px 9px;text-align:left}.prose ul{padding-left:22px}
@media(min-width:1400px){.hero{padding-top:72px;padding-bottom:63px}}
@media(max-width:900px){.nav{gap:25px}.professional{display:none}.nav nav{margin-left:auto}.hero{gap:20px}.hero-note{min-width:175px;padding-left:20px}h1{font-size:38px}.calculator-grid{grid-template-columns:1.12fr 1fr;gap:18px}.form-card{padding:26px 23px 20px}.result-card{padding:24px 23px}.profiles-grid{gap:18px}.profile{padding:23px}.how-section,.about-section{gap:45px}.footer>.wrap{flex-wrap:wrap}.footer p{display:none}}
@media(max-width:640px){.wrap{padding:0 21px}.header{height:77px}.nav{gap:15px}.brand{font-size:20px}.brand-icon{width:29px;height:29px;border-radius:8px;font-size:18px;margin-right:8px}.nav nav{gap:16px;font-size:11px}.nav nav a:last-child{display:none}.hero{padding:39px 0 34px;display:block}.hero .eyebrow{font-size:8px;letter-spacing:1.2px}h1{font-size:34px;letter-spacing:-1.4px;line-height:1.14}.hero-text{font-size:13px}.hero-note{display:none}.desktop{display:none}.section-heading{align-items:flex-end;margin-bottom:18px}.section-heading h2{font-size:24px}.section-heading .eyebrow{font-size:8px;letter-spacing:1.3px}.text-button{font-size:10px;gap:4px}.text-button span{max-width:78px;line-height:1.5;text-align:right}.calculator-grid,.profiles-grid,.how-section,.about-section{grid-template-columns:1fr}.form-card{padding:25px 23px 20px}.step-heading h3{font-size:18px}.step-heading p{font-size:11px}select,input[type=text]{font-size:16px}.result-card{padding:24px;min-height:300px}.empty-result{padding:32px 0}.empty-symbol{margin-bottom:12px}.empty-result h3{font-size:24px}.empty-result p{font-size:11px}.result-footer{padding-top:16px}.result-content{padding:21px 0}.dose-result{font-size:57px}.result-label{margin-top:25px}.profiles-section{margin-top:36px}.small-label{display:none}.profiles-grid{gap:15px}.profile h3{font-size:19px}.profile .detail-row{font-size:12px}.how-section{margin-top:36px;padding:33px 0;gap:30px}.how-section h2,.about-section h2{font-size:28px}.how-section>div>p:last-child{max-width:100%}.how-section li h3{font-size:14px}.how-section li p{font-size:12px}.about-section{padding:33px 0;gap:23px}.clinical-notice{padding:20px 17px;margin-bottom:35px}.clinical-notice p{font-size:11px}.footer{padding:23px 0}.footer>.wrap{gap:19px}.footer .brand{font-size:18px}.footer nav{width:100%;gap:22px;margin:0;font-size:11px}.prose{padding:24px;margin-top:25px;font-size:13px}.prose h1{font-size:28px}.prose table{font-size:11px}dialog{padding:29px 24px}dialog h2{font-size:26px}}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}*{transition:none!important}}
/* Version 2 label-based reference controls */
input[type=search],.patient-grid input{width:100%;border:1px solid #dcc6df;border-radius:9px;background:#fff;color:var(--ink);height:45px;padding:0 12px;font:inherit;font-size:13px}input[type=search]{margin-bottom:14px;background:#fff9fd}.patient-grid{display:grid;grid-template-columns:1fr 1fr;gap:15px;margin:20px 0}.patient-grid>div:first-child{grid-column:1/-1}.context-label{margin-top:19px}.patient-grid label{font-size:11px}.profile-ingredient{font-size:11px;color:var(--subtle);margin:-10px 0 22px}.profile-sources{border-top:1px solid var(--line);padding-top:18px;margin-top:12px;font-size:11px}.profile-sources p{margin:10px 0 0}.profile-sources small{font-size:10px;color:#7a6085}.result-schedule{font-size:14px;font-weight:600}.result-source{font-size:11px;margin-top:20px}.result-description{color:#6a4075}.calculator-grid{align-items:start}.result-card{min-height:450px;position:sticky;top:24px}.profile .detail-row{grid-template-columns:34% 66%}.profile dd{font-size:11px}.form-foot{line-height:1.7}.dose-control[hidden]{display:none}.hero-note{min-width:210px}@media(max-width:640px){.result-card{position:static;min-height:310px}.patient-grid{grid-template-columns:1fr}.patient-grid>div:first-child{grid-column:auto}.profile .detail-row{grid-template-columns:1fr;gap:4px}.profile dd{font-size:12px;padding-right:0}input[type=search],.patient-grid input{font-size:16px}.hero h1{font-size:33px}}

/* Explicit evidence distinction for clinical comparisons. */
#evidence-mode{margin-bottom:8px}.form-card>#evidence-mode+.help{margin-bottom:28px}.estimate-badge{display:inline-block;margin:20px 0 8px;padding:8px 12px;background:#f2d9a4;color:#5b3904;border-radius:6px;font-size:11px;font-weight:800;letter-spacing:.07em}.estimate-warning{font-size:14px;font-weight:650;color:#6b4207;line-height:1.6}.calculation-steps{margin:20px 0;padding:16px;background:#ffffff90;border-radius:10px;font-size:13px;line-height:1.6}.calculation-steps ol{padding-left:20px}.calculation-steps li+li{margin-top:8px}

.legacy-output{margin:16px 0;line-height:1.6}.legacy-output div{font-size:14px!important}.supplemental-profile{margin-top:24px;border-top:1px solid #e8cddd;padding-top:18px}.supplemental-profile summary{cursor:pointer;font-weight:700}

/* Purple and pink palette: shared across calculator and information pages. */
.primary-button{background:#a52d70}.primary-button:hover:not(:disabled){background:#862259}.brand-icon{background:#633478}.hero-note .note-symbol{color:#a52d70}